Fixation Device to Measure the Contractile Force of Skeletal Muscle in Live Animals Public
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The goal of this project was to design a relatively inexpensive, minimally invasive fixation device for the hind limb of a mouse that uses topical electrical stimulation of skeletal muscle to accurately and repeatedly quantify the force generated by muscle contractions. The device also had to be compatible with surgical procedures visualized using a stereomicroscope. Measurements were acquired following multiple series of electrical stimulation by placement of bipolar electrodes on the tibialis anterior muscle surface. There was no visible evidence of tissue damage at either the knee anchor point or at the point of attachment of ligature to the foot, which was connected to the force transducer. Further, there was no visible damage to the muscle tissue due to electrode placement.
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