Synthesis of a Paramagnetic Myeloperoxidase Substrate with Superoxide Dismutase Activity
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open in viewerA scheme was constructed for synthesizing a MRI contrast agent with both MPO sensing and SOD therapeutic ability. This contrast agent was designed by modifying a previously published paramagnetic SOD mimetic with therapeutic ability to contain a substrate group for MPO. This allows the contrast agent to accumulate in sites of high MPO concentration, increasing MRI signal intensity. The scheme relies on economic dipicolinic acid as a starting material for the functionalized ligand. The reaction intended to be utilized to attach the MPO substrate is an environmentally-friendly “click chemistry” reaction. Both synthetic building blocks for the click chemistry reaction were synthesized and characterized and a new, final scheme was devised in order to increase yield and convenience.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Colaboradores
- Publisher
- Identifier
- E-project-060113-012851
- Advisor
- Year
- 2013
- Sponsor
- Date created
- 2013-06-01
- Resource type
- Major
- Rights statement
- Última modificación
- 2020-11-19
Las relaciones
- En Collection:
Elementos
Elementos
Miniatura | Título | Visibilidad | Embargo Release Date | Acciones |
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GF_MQP.pdf | Público | Descargar | ||
MQP_poster_revised.pdf | Público | Descargar |
Permanent link to this page: https://digital.wpi.edu/show/cc08hh20d