A scheme was constructed for synthesizing a MRI contrast agent with both MPO sensing and SOD therapeutic ability. This contrast agent was designed by modifying a previously published paramagnetic SOD mimetic with therapeutic ability to contain a substrate group for MPO. This allows the contrast agent to accumulate in sites of high MPO concentration, increasing MRI signal intensity. The scheme relies on economic dipicolinic acid as a starting material for the functionalized ligand. The reaction intended to be utilized to attach the MPO substrate is an environmentally-friendly “click chemistry” reaction. Both synthetic building blocks for the click chemistry reaction were synthesized and characterized and a new, final scheme was devised in order to increase yield and convenience.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Feula, Giancarlo

Colaboradores

• Bogdanov, Alexei

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-060113-012851

Advisor

• Brodeur, Drew R.
• Heilman, Destin

Year

• 2013

Sponsor

• University of Massachusetts Medical Center, Worcester Massachusetts

Date created

• 2013-06-01

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright

Última modificación

• 2020-11-19