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Cross-talk between Beta1 Integrins and Insulin-like Growth Factor I Receptor in Prostate Cancer

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The insulin-like growth factor I receptor (IGF-IR) and beta1 integrins promote various cellular events such as migration and proliferation that are important to prostate cancer development. Downregulation of beta1 causes subsequent downregulation of IGF-IR in human prostate cancer LNCaP cells. Expression of IGF-IR was found to be comparable in prostate sections from wild type and prostate specific beta1 conditionally ablated TRAMP mice, a mouse model for prostate cancer. By analyzing the downstream signaling of IGF-IR, the levels of phosphorylated Akt were found to be unaffected by downregulation of beta1 integrins and IGF-IR. This study suggests that beta1 integrins may play a key role in the regulation of IGF-IR expression.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042408-112400
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  • 2008
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  • 2008-04-24
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