The insulin-like growth factor I receptor (IGF-IR) and beta1 integrins promote various cellular events such as migration and proliferation that are important to prostate cancer development. Downregulation of beta1 causes subsequent downregulation of IGF-IR in human prostate cancer LNCaP cells. Expression of IGF-IR was found to be comparable in prostate sections from wild type and prostate specific beta1 conditionally ablated TRAMP mice, a mouse model for prostate cancer. By analyzing the downstream signaling of IGF-IR, the levels of phosphorylated Akt were found to be unaffected by downregulation of beta1 integrins and IGF-IR. This study suggests that beta1 integrins may play a key role in the regulation of IGF-IR expression.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Butterfield, Julie Elyssa

Mitwirkende

• Languino, Lucia R.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042408-112400

Advisor

• Politz, Samuel M.

Year

• 2008

Sponsor

• University of Massachusetts Medical School

Date created

• 2008-04-24

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Zuletzt geändert

• 2023-10-06