Mechanism for Interferon Production
PubblicoCompounds that stimulate interferon production in cells might have therapeutic effects against viruses that prevent the activation of interferon production. Our lab previously identified a compound as potential up-regulators of interferon production.. This project confirmed the effects of the compound and then analyzed the mechanism of interferon production using RT-PCR, bioassays, nanostring assays, and residual viral levels in vitro to determine the ability of the compounds to protect against viral infection. The results show that interferon production can be stimulated in a variety of cell lines (HEK293 cells, macrophages, dendritic cells, and fibroblast cells) and the protein RIG-I is necessary for interferon production by the compound.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Contributori
- Publisher
- Identifier
- E-project-032212-091007
- Advisor
- Year
- 2012
- Sponsor
- Date created
- 2012-03-22
- Resource type
- Major
- Rights statement
- Ultima modifica
- 2023-10-09
Relazioni
- In Collection:
Articoli
Elementi
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Jacquelin_AB_Crouse_and_Casey_A_Krawic_MQP_Report_2011_-_2012.pdf | Pubblico | Scaricare |
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