Mechanism for Interferon Production
PublicDownloadable Content
open in viewerCompounds that stimulate interferon production in cells might have therapeutic effects against viruses that prevent the activation of interferon production. Our lab previously identified a compound as potential up-regulators of interferon production.. This project confirmed the effects of the compound and then analyzed the mechanism of interferon production using RT-PCR, bioassays, nanostring assays, and residual viral levels in vitro to determine the ability of the compounds to protect against viral infection. The results show that interferon production can be stimulated in a variety of cell lines (HEK293 cells, macrophages, dendritic cells, and fibroblast cells) and the protein RIG-I is necessary for interferon production by the compound.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Contributors
- Publisher
- Identifier
- E-project-032212-091007
- Advisor
- Year
- 2012
- Sponsor
- Date created
- 2012-03-22
- Resource type
- Major
- Rights statement
- Last modified
- 2023-10-09
Relations
- In Collection:
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Jacquelin_AB_Crouse_and_Casey_A_Krawic_MQP_Report_2011_-_2012.pdf | Public | Download |
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