ACTIVATION OF MACROPHAGES IN VIVO BY GLYCAN LNFPIIIPublic
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LNFPIII, a schistosome glycan, has been shown to induce an anti-inflammatory response in vivo and in vitro. In this study we demonstrate the effects that LNFPIII has on macrophages using mouse models. When mice are injected with LNFPIII-dex the production of inflammatory cytokine IL-6 is significantly decreased, compared to uninjected and dextran injected mice. We also found that macrophages from LNFPIII injected mice show signs of alternative activation, including the upregulation of Arginase-1. LNFPIII-activated macrophages also express higher levels of the surface markers CD80 and PDL-1. Lastly, LNFPIII- activated macrophages were able to prime T cells in vitro as seen by a decrease in the production of IFN Gamma and IL-13.
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