Zinc photocages have the potential to map signaling pathways provided that molecular and photophysical properties continue to improve. The group is working towards developing these types of molecules as a way to deliver zinc ions to cells that will play a role in various biological processes. Under the correct conditions these molecules undergo photodecarboxylation leaving behind ligands that do not bind well to zinc ions leaving free zinc available to cells. In this project, there is an attempt to utilize 8-aminoquinoline as a ligand and sensitizer to create a bathochromic zinc photocage. The antenna effect is explored by using 8-aminoquinoline as the sensitizer to harvest the UV-light and transfer the energy to the target chromophore lowering the amount of energy required for decarboxylation to occur. This means when uncaging the usage of harmful wavelengths of light can be mitigated. 8AQdeCage is developed and the photophysical properties are explored.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Frederique, Isaac

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042723-171635
• 106666

Keyword

• Photocage
• Zinc
• Organic synthesis
• biological applications

Advisor

• Burdette, Shawn C

Year

• 2023

Date created

• 2023-04-27

Resource type

• Major Qualifying Project

Major

• Chemistry

Source

• E-project-042723-171635

Rights statement

• In Copyright

Last modified

• 2024-04-03