Student Work
Sequence analysis of CP and NCP HIV-1 clones
PublicTwo HIV-1 clones that have different cytopathogenicity were previously isolated from a single patient. In this MQP PCR amplification of the env, gag, nef, and vpr regions of the two clones was performed. Sequencing of the two clones was done to identify sequence variations potentially responsible for the difference in cytopathogenicity. The vpr sequence of the noncytopathic clone revealed an early stop codon resulting in a truncated protein. This is a significant difference and is a likely candidate for affecting the cytopathogenicity.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 99D110M
- Advisor
- Year
- 1999
- Sponsor
- Date created
- 1999-01-01
- Resource type
- Major
- Rights statement
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