Student Work
Identification of Yeast Deubiquitinating Enzyme (DUB) Substrates
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open in viewerE3 ubiquitin ligases, such as SCFGrr1, are enzymes that add ubiquitin chains to proteins targeting them to the proteasome for degradation. Deubiquitinating enzymes (DUBs) can counteract this activity by removing ubiquitin chains and thus rescue proteins from degradation. Our goal was to develop genetic and biochemical screening approaches to identify DUB substrates, and thus learn more about DUBs that may contribute to human disease. Our data suggests that the yeast DUBs Ubp3 and Ubp12 affect the stability of the Grr1 targets Cln2, Cln3, and Gic2.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-010912-184218
- Advisor
- Year
- 2012
- Sponsor
- Date created
- 2012-01-09
- Resource type
- Major
- Rights statement
Relations
- In Collection:
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Pamela_Stanley,_MQP_Final-2.pdf | Public | Download |
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