Macrophage CD40 Signaling Involving TRAF6 Releases Neurotoxic Proteins
PublicContenu téléchargeable
open in viewerHIV- associated dementia (HAD) is a common central nervous disorder that occurs in the late stage of HIV-1 infection. The mechanisms of how HIV-1 induces HAD are poorly understood. Direct injury to neurons might result from viral proteins, while indirect injury to neurons could occur through toxins released by microglia, macrophages, and astrocytes. In this project we show that TRAF6 protein is a mediator of the CD40 signaling pathway in macrophages, and that products released by macrophages upon stimulation by CD40L are neurotoxic. Fractionation of supernatants from CD40L-stimulated macrophages showed that the neurotoxic factor may be between 3-30 kD, and further tests demonstrated that the factor might be a protein or protein-associated.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Contributeurs
- Publisher
- Identifier
- E-project-011007-110636
- Advisor
- Year
- 2007
- Sponsor
- Date created
- 2007-01-10
- Resource type
- Major
- Rights statement
Relations
- Dans Collection:
Contenu
Articles
La vignette | Titre | Visibilité | Embargo Release Date | actes |
---|---|---|---|---|
EliseNakamuraMQPFinal.pdf | Public | Télécharger |
Permanent link to this page: https://digital.wpi.edu/show/9w032465h