DNA Sequence Analyses and Error Correction
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open in viewerAdvances in error correction for next generation sequencing have not matched increases in data production and as a result, the quality of the generated nucleotide sequences has suffered. The purpose of this project was to develop a processing pipeline which would remove errors from intensity data for a faster and more accurate analysis. The method employed to achieve these goals was to redesign the algorithm used to correct for bleaching and phasing to capture a greater number of misidentified bases. Two pipelines were created, pipeline 1 (illumina) and pipeline 2 (Oracle ), it was determined that pipeline 2 out preformed pipeline one in terms of accuracy. But pipeline 1 was determined to be faster in processing time and thus the main question is asked do you sacrifice time for efficiency?
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Colaboradores
- Publisher
- Identifier
- E-project-043014-172052
- Advisor
- Year
- 2014
- Date created
- 2014-04-30
- Resource type
- Major
- Rights statement
Relações
- Em Collection:
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Itens
Miniatura | Título | Acesso | Embargo Release Date | Ações |
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DNA_Sequence_Analyses_and_Error_Correction.pdf | Público | Baixar |
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