SimCortex 2.0 was created as an interactive graphical simulation of the development of the cerebral cortex in the mouse. Progenitor proliferation, neuronal migration along glial fibers, and cell death are modeled. As the simulation progresses, radial glia defasciculate and transform morphologically, and neurons travel to their destined layers. The user can alter the simulated development by manipulating probabilistic processes to experiment with the results. Characteristics of cerebral development were successfully validated within the simulation when compared to current research data.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Horan, Jessica Ellen.
• Frantz, Marybeth E.
• Douglas, Benjamin John.
• Theriault, Tanya Yvonne.

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D008M

Advisor

• Ryder, Elizabeth F.
• Ward, Matthew O.

Year

• 2000

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology
• Computer Science

Rights statement

• In Copyright