HIV-1 uses specific cell surface receptors to gain entry into host cells. Different strains vary in ability to infect cells with low receptor concentrations. The MQP's purpose was to analyze molecular clones of an HIV variant that had broad tropism for immune cells. These clones were tested for their ability to fuse with cells expressing known receptor concentrations. The data shows that this HIV variant was more fusiogenic for cells with low receptor expression than the wild type strain.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Salomon, William Edward

Contributors

• Paul Clapham

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042805-143027

Advisor

• Adams, David S.

Year

• 2005

Sponsor

• University of Massachusetts Medical Center

Date created

• 2005-04-28

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright