Casein kinase-1-Delta(CK1d) is an enzyme known to phosphorylate several key proteins in the circadian rhythm cycle, and in particular to phosphorylate Per to induce its movement back into the nucleus to regulate the circadian period. Two previous studies (Xu et al. 2005; Machida 2007) indicated CK1d knock out (KO) mice may be unable to survive to birth. Data from this MQP indicate some of the KO pups actually survive to gestational day (GD) 20, very near birth, and the morphology of their major organs equals that of wild type mice, which provides hope that if several of these mice can be kept alive, the reason for their death may be discovered and CK1d's role may be better understood.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Conde, Haley Marie

Contributors

• Weaver, David

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-010908-144949

Advisor

• Adams, David S.

Year

• 2008

Sponsor

• UMass Medical School

Date created

• 2008-01-09

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright