The goal of this project was to document and evaluate the technology of cancer vaccines, to determine whether they are worth the recent media hype, to document any associated problems, and to help prioritize future directions. We performed a review of the research literature and conducted interviews with academic cancer researchers. Based on the data, of the six major categories of cancer vaccines, tumor infiltrating lymphocyte (TIL) and chimeric antigen receptor (CAR) vaccines have shown the highest efficacies. In the future, we recommend using combination vaccines (especially with antibodies for immune checkpoint inhibitors), adjuvants, recall antigens, and identifying and using a patient's own specific tumor neo-antigens. We recommend that funding be continued for this research.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Healy, Danielle Kathleen
• Vrooman, Isaac Henry
• Kassas, Anthony Abraham
• Williams, Eric Yit
• Brinkmann, Derek Michael

Subject

• Health
• Well-Being
• Industry
• Innovation
• Security

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-082615-140614

Palabra Clave

• Medical care

Advisor

• Adams, David S.

Year

• 2015

Date created

• 2015-08-26

Ubicación

• Worcester

Resource type

• Interactive Qualifying Project

Rights statement

• In Copyright

Última modificación

• 2022-04-01