Student Work
Effects of Gαq-PLCβ Pathway Activation on Cellular Calcium and Mitochondrial Activity
PublicDownloadable Content
open in viewerThe Gαq-PLCβ pathway is triggered when a neurotransmitter, hormone, or other signalling molecule binds to a G-protein coupled receptor located on the surface of the cell membrane. This results in a series of steps that lead to increased levels of cellular calcium ions. In this project, fluorescent sensor dyes and intrinsic fluorescence of NADH/NAD+ were used to show that increased levels of intracellular calcium ions after carbachol stimulation occur in parallel with increased mitochondrial activity and oxidative stress in the mitochondria.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Subject
- Publisher
- Identifier
- E-project-050621-132132
- 22971
- Keyword
- Advisor
- Year
- 2021
- Date created
- 2021-05-06
- Resource type
- Major
- Rights statement
- Last modified
- 2021-08-29
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Vail -Biochemistry MQP.pdf | Public | Download |
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