An anti-inflammatory system was created to reduce the inflammation and fibrotic scarring caused by a subcutaneous biosensor. This system was comprised of Titania nanotubes, chitosan hydrogel, and drug-releasing nanoparticles, and was aimed at reducing the adhesion and activation of macrophages. Testing suggests that the system reduces macrophage activity, and therefore the subsequent fibrotic encapsulation, in comparison to Ti foil, TiO2 nanotubes, and chitosan hydrogel acting in isolation.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Kenney, Macauley Reardon
• Bannish, Catherine Anne
• Vazquez, Keila M.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042513-120109

Advisor

• Jain, Anjana
• Zhou, H Susan

Year

• 2013

Date created

• 2013-04-25

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright

Last modified

• 2021-02-04