THE FUNCTIONAL IMPORTANCES OF KEY POSITIONS OF THE WT 3K PEPTIDE CORRESPONDING TO THE 506 AND 508 T-CELL RECEPTORS AND ITS IMPLICATIONS FOR NEGATIVE SELECTIONPublic
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The generation of the T cell receptor (TCR) repertoire is an essential process for the adaptive immune system. The development of a functional TCR involves random genetic recombination in which a diverse group of TCRs must be developed while avoiding combinations that would target self-antigens. By investigating a WT peptide and its variations between two TCRs we are able to perceive the differences between the two, demonstrating key points essential to both TCRs along with key functional locations that are distinct for each TCR. Through this research we begin to understand the structural variation that presents itself during the development of separate TCRs.
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