zf35 is a mutation in the unc-2 gene of C. elegans that causes a hyperactive phenotype. unc-2 encodes the alpha-1a subunit of a P/Q type calcium channel involved in synaptic transmission in C. elegans. Double mutants were constructed of zf35 and known synaptic transmission mutants egl-30, unc-13, snt-1, and unc-31, to determine how zf35 affects neurotransmitter release. Also, a genetic screen was done to identify mutations that suppress the zf35 phenotype, revealing novel genes in this pathway. We conclude that zf35 mutants have defects in the presynaptic pathway.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Raj, Samuel Luke
• Sarin, Dhruv

Contributors

• Alkema, Mark

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-011309-180004

Advisor

• Adams, David S.

Year

• 2009

Sponsor

• Umass Medical Center

Date created

• 2009-01-13

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2023-09-28