Gender-based Differences in Parkinson’s Disease and Amyotrophic Lateral Sclerosis Expression in C. elegansPublic
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Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are common neurodegenerative disorders exhibiting male gender biases. The gender-related differences at both symptomatic and therapeutic levels are not understood. We developed C. elegans models for studying both disorders, and examined gender differences in symptom presentation using behavioral assays measuring locomotion and chemosensory abilities. Symptoms exhibiting gender bias had limited presentation in our models. Additionally, we investigated the efficacy of two potential treatments, caffeine and vanillin. We found that while treatment with caffeine had mixed results based on disease type, vanillin reduced neuronal deficits in both PD and ALS models.
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