Development of a Perfusion Based System for Cardiac Decellularization
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open in viewerHeart failure is one of the leading causes of death worldwide. Currently, heart transplantation is the treatment of choice for end-stage heart failure, but lack of donor hearts and risk of rejection remain a challenge. Research has shown that decellularized hearts, in which cells are removed from the cardiac extracellular matrix (ECM), can provide a scaffold for use in engineering patient-specific heart transplants. This project presents a low-cost, semi-automated, small-organ (ie. rat heart) decellularization bioreactor designed for cardiac research, Testing has shown that this device can successfully decellularize rat hearts, and offers functionality similar to commercial devices.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-043015-002234
- Advisor
- Year
- 2015
- Date created
- 2015-04-30
- Resource type
- Major
- Rights statement
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项目
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