Deducing Function Through Localization: PCV1 VP3 The Problem Child

Millard, Daniel C.

Student Work

Deducing Function Through Localization: PCV1 VP3 The Problem Child Public

The Circoviridae family of viruses have several members that encode proteins observed to induce apoptosis in human cells with specificity towards cancer cells. One unique example, PCV1-VP3, has significant morphological and functional differences, possessing an additional tail domain and localizing in the cytoplasm rather than the nucleus of transformed cells. To gain insight into possible mechanisms of action, compartmentalization of PCV1-VP3 was investigated using differential detergent fractionation and fluorescent microscopy.

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