INFLUENZA POLYMERASE COMPLEX: Novel Antiviral Drugs and Polymerase FidelityPublic
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The Influenza A virus is a highly pathogenic virus with the potential to cause major pandemics and annual outbreaks. The goal of this project is to investigate the highly conserved trimeric polymerase complex of the virus, which is needed for viral replication and transcription. We developed the reagents for a fluorescence polarization assay, which can identify small molecules that disrupt the interactions within the complex, and have the potential to be a new anti-viral drug. This project also developed a transcription assay system to test the polymerase fidelity.
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