This project investigated the function and mechanism of actin and myosin II related cytokinesis in normal rat kidney cells. Cytokinetic inhibitory drugs such as Blebbistatin and Cytochalasin D were used to study the origin of midzone microtubules and the global effects of cleavage failure in dividing cells. Micromanipulation experiments were done to test local effects of such drugs on equatorial and polar cortices of the cell. Results indicated the significant role of myosin II in the polar region that contributes to cleavage furrow.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Guha, Minakshi

Publisher

• Worcester Polytechnic Institute

Identifier

• 03B011M

Advisor

• Argüello, José M.
• Wang, Yu-Li

Year

• 2009

Sponsor

• UMass Medical School

Date created

• 2009-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright