There is a critical need for pharmacokinetic research involving pregnant and breastfeeding women as few drugs provide safety information regarding the medications’ effect on the mother and fetus. Lithium carbonate, the only anti-suicidal treatment for bipolar disorder, is a known teratogen without a non-teratogenic alternative. Our team investigated a lipid nanoparticle drug delivery system for the delivery of lithium carbonate to minimize placental and mammary cell uptake. Several nanoparticle formulations were tested and none were successful in encapsulating the drug, however a method for quantification of particle loading was successfully identified. Additional research is needed to formulate a delivery system for the continuation of lithium treatment during pregnancy and lactation.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Ossing, Sarah
• Condon, Kayla
• Carlin, Cameron
• Smiarowski, Violet

Subject

• Health
• Inclusion
• Well-Being

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042424-183857
• 121581

Palabra Clave

• Pregnancy
• Women's health
• Lactation
• Drug delivery
• Lipid nanoparticle
• Lithium carbonate

Advisor

• Alatalo, Diana
• Bailey, Christina M.

Year

• 2024

UN Sustainable Development Goals

• 3 - Good Health and Well-being
• 5 - Gender Equality
• 10 - Reducing Inequality

Date created

• 2024-04-24

Resource type

• Major Qualifying Project

Major

• Chemical Engineering
• Biomedical Engineering

Source

• E-project-042424-183857

Rights statement

• In Copyright

Última modificación

• 2024-05-23