Experiments were designed to confirm the reliability of an Aspen Plus model simulating an active pharmaceutical ingredient recovery process for Sunovion Pharmaceuticals. The process includes a reaction between a triflate salt compound and potassium hydroxide, followed by a liquid-liquid extraction with methyl tert-butyl ether. The experiments looked to verify the previous work, study the effects of pH above pKa on the reaction, and study the effects of temperature on the extraction. Other solvents were examined for feasibility in the process.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Gagnon, Kyle
• Cheung, Alan Yu-Loon
• Smith, Sean Maurice
• Pai, Vinay
• Smith, Sean

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042815-215151

Advisor

• Clark, William M.

Year

• 2015

Sponsor

• Sunovion Pharmaceuticals

Date created

• 2015-04-28

Resource type

• Major Qualifying Project

Major

• Chemical Engineering

Rights statement

• In Copyright