Student Work

Synthesis of Near-IR Fluorophores Towards In Vivo Protein Detection

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Recent studies into oxazine derivative dyes have shown promising shifts in excitation and emission properties. For this MQP, the synthesis and spectral properties of two oxazine derivatives: 4-Ethyl-3,8,9,10-tetrahydro-2H-1,6,11-trioxa-8,13-diaza-4-azonia-pentacene; chloride (7) and 8-(3-Ethoxycarbonyl-propyl)-4-ethyl-3,8,9,10-tetrahydro-2H-1,6,11-trioxa-8,13-diaza-4-azonia-pentacene; chloride (8, 9) were studied. The electronic excitation and emission properties of compound 9 were examined in incremental pH solutions ranging from 1 to 11. In methanol maximum excitation of compound 9 was observed at 648.0 nm while maximum emission occurred at 674.26 nm. Consistency in the excitation and emission spectra show that compound 9 has strong pH stability.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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贡献者
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Identifier
  • E-project-042910-162108
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Year
  • 2010
Sponsor
Date created
  • 2010-04-29
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