Biocompatible polymer-coated nanoparticles are at the forefront of research into the ever expanding field of drug delivery. We synthesized a reactive O-imidazolide precursor of methoxy polyethylene glycol (MPEG) and linked it to poly-L-lysine of two separate molecular masses to synthesize biocompatible protected graft copolymers (MPEG-gPLL). MPEG-gPLLs were then used for coating gold nanoparticles obtained in the presence of citrate as a capping/reducing reagent. We also performed the assessment of stabilization using surface plasmon changes and fluorescence spectroscopy and determined the appropriate concentrations of PGC to be between 0.0156 and 0.004 mg/ml and nanoparticles to be 0.99 mg/ml for optimal binding to the surface of the nanoparticles.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Elmore, William Melvin

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042513-103117

Advisor

• Brodeur, Drew R.

Year

• 2013

Sponsor

• University of

Date created

• 2013-04-25

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright

Last modified

• 2020-11-19