Acne is the eighth most prevalent disease worldwide. Current treatments include over-the- counter and prescription options, both of which are inadequate due to adverse effects such as redness and inflammation of the skin, and antibiotic resistance on the rise, respectively. Antimicrobial peptides (AMPs) have been investigated as a promising alternative, but have suffered due to their high cost, cytotoxic risk and challenge of delivering a large protein through the skin barrier. This project aimed to develop a topical antimicrobial peptide delivery vehicle to deliver modified AMP fCBD-LL37 to the sebaceous glands in the skin for the safe and effective treatment of acne vulgaris.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Mace, Joshua B.
• Hanson, Abigail
• Sherlock, Nicole
• Metters, Frederick T.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042418-151432

Advisor

• Rolle, Marsha Whitney

Year

• 2018

Date created

• 2018-04-24

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Source

• E-project-042418-151432

Rights statement

• In Copyright

Last modified

• 2024-05-13