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Regulation of HIF Expression in Human Fibroblasts Public

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It has been found that hypoxia is an advantageous condition for the culture of pluripotent stem cells. Hypoxia-inducible factors (HIFs), are transcription factors involved in the mediation of a hypoxic response. HIF has downstream gene targets that have implications in pluripotency. The current research attempts to characterize their activity in human adult fibroblasts. Specifically, it aims to determine if HIFs are responsive to hypoxia in fibroblasts and whether their regulation is affected at transcriptional, translational or post-translational levels. Further, HIF localization was examined as an implication of protein function. It was found that HIFs are expressed in fibroblasts, but the hypoxic response is different than observed in human embryonic stem cells.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
  • E-project-042711-142942
  • 2011
Date created
  • 2011-04-27
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