SORMSAM
PúblicoThis Major-Qualifying Project examined the potential of using enzymes in a continuous flow process using self-assembly scaffolds.The first recorded observations of differences in the biological actions of stereoisomers was in 1886. Since then, there have been many chiral drugs identified to have adverse side effects due to an enantiomer in a drug and/or human pharmacotherapies that cannot be easily separated from its racemate. I explored the different methods of separating racemates and found the best scaffold to covalently bond self-assembling monolayers (SAM) with the enzyme carboxylesterase naproxen (CNP). The final design is a proposal for how we can develop this idea with these parts.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-121621-051105
- 43456
- Advisor
- Year
- 2021
- Date created
- 2021-12-16
- Resource type
- Major
- Rights statement
Relações
- Em Collection:
Itens
Itens
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Separation of Racemates Using Self-Assembling Monolayers (MQP).pdf | Público | Baixar |
Permanent link to this page: https://digital.wpi.edu/show/5425kd78n