This Major-Qualifying Project examined the potential of using enzymes in a continuous flow process using self-assembly scaffolds.The first recorded observations of differences in the biological actions of stereoisomers was in 1886. Since then, there have been many chiral drugs identified to have adverse side effects due to an enantiomer in a drug and/or human pharmacotherapies that cannot be easily separated from its racemate. I explored the different methods of separating racemates and found the best scaffold to covalently bond self-assembling monolayers (SAM) with the enzyme carboxylesterase naproxen (CNP). The final design is a proposal for how we can develop this idea with these parts.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Newlon, Zachary

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-121621-051105
• 43456

Advisor

• Young, Eric Mosher

Year

• 2021

Date created

• 2021-12-16

Resource type

• Major Qualifying Project

Major

• Chemical Engineering

Rights statement

• In Copyright