Parasitic nematodes may evade host immune systems by changing surface composition during infection. C. elegans is a free-living nematode with a conserved development and cuticle structure utilized as a parasitic model. srf-6 mutant worms fail to make surface antigen switches that occur facultatively in the wild type. The whole genome sequences of three srf-6 mutants were determined to identify the DNA sequence corresponding to srf-6. This project’s objective was to find and confirm srf-6 mutations in the genome sequence by re-sequencing the candidate gene in mutant DNA.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Van Sciver, Nicholas Donald
• Rush, Caitlin T.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050114-163547

Advisor

• Politz, Samuel M.
• Dempski, Robert E.

Year

• 2014

Date created

• 2014-05-01

Location

• Worcester

Resource type

• Major Qualifying Project

Major

• Biochemistry
• Biology & Biotechnology

Rights statement

• In Copyright