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Investigating Transcriptional Regulation of C. elegans Insulin-like Genes

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The highly conserved insulin/insulin-like growth factor signaling (IIS) pathway plays a critical role in development, lifespan, and metabolism. In the nematode, Caenorhabditis elegans, there are 40 insulin-like genes. Here, I investigate the transcriptional regulation of one insulin-like gene, ins-27, by knocking down transcription factor expression via RNA interference. I identified sixty five transcription factors as potential regulators of ins-27. By investigating regulators of C. elegans insulin-like genes, we may learn more about the biological processes that modulate insulin expression. This may provide greater insight into the regulation of human insulin-like genes.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042513-143119
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  • 2013
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  • 2013-04-25
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