In this project, the proteomes of Ebola and its deadly relatives from the Filoviridae (Filovirus) family are studied to better understand the evolution of these viruses that may help in developing better antiviral drugs and vaccines. Specifically, we construct three-dimensional models for the seven proteins in the proteome using the homology modeling approach. Then, we find the conserved and diverse regions in each protein across species and annotate them with the protein binding sites involved in virus-virus interactions and in human-virus interactions. We conclude that highly conserved regions are linked to the areas involved in virus-virus interactions, while the highly diverse regions are linked to those involved in human-virus interactions.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Zhao, Yifan

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-091115-162004

Advisor

• Korkin, Dmitry

Year

• 2015

Date created

• 2015-09-11

Resource type

• Major Qualifying Project

Major

• Bioinformatics & Computational Biology

Rights statement

• In Copyright

License

• All rights reserved