Recently, the malaria-causing parasite Plasmodium falciparum has acquired resistance to treatment with pure artemisinin, a drug compound produced by the plant Artemisia annua. Oral consumption of dried leaves of Artemisia annua has been proposed as an effective and more affordable therapeutic alternative. To investigate this treatment, Caco-2 cell monolayers were used to study the effect of two flavonoids, quercetin (Q) and rutin (R), on artemisinin (AN) transport and bioavailability. This study demonstrated that quercetin and rutin may have increased artemisinin transport.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Hayes, Brianna Susan
• Harten, Kate Lebzelter
• Burns, Laura Marie

贡献者

• Cambra, Cambra
• Purnell, Jason

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043014-150952

Advisor

• Weathers, Pamela

Year

• 2014

Date created

• 2014-04-30

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright