Effect of cannabinoids (CBD) on worm behavior and physiology 2023-2Public Deposited
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The purpose of this project was to determine if Cannabidiol could be used to reduce the behavioral effects of 6-OHDA induced Parkinson’s Disease in C. elegans. Behavioral assays measuring thrashes, Omega-, and Delta-turns in liquid media were used to analyze restorative abilities CBD had on the movement of the worms. It was found that CBD was able to increase thrashing behavior from 20/minute to 40/minute in PD worms, and was able to decrease time spent in turns by half. Although conclusions were heavily limited by sample size of the data collected, this project provides preliminary evidence in support of CBD restoring normal movement behaviors for PD-model worms.
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