The purpose of this project was to determine if Cannabidiol could be used to reduce the behavioral effects of 6-OHDA induced Parkinson’s Disease in C. elegans. Behavioral assays measuring thrashes, Omega-, and Delta-turns in liquid media were used to analyze restorative abilities CBD had on the movement of the worms. It was found that CBD was able to increase thrashing behavior from 20/minute to 40/minute in PD worms, and was able to decrease time spent in turns by half. Although conclusions were heavily limited by sample size of the data collected, this project provides preliminary evidence in support of CBD restoring normal movement behaviors for PD-model worms.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Holbrook, Amanda
• Behning, Claire

Subject

• Health
• Innovation

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042623-234731
• 105676

Keyword

• C. elegans
• Parkinson's Disease
• CBD
• Behavior

Advisor

• Srinivasan, Jagan
• Scarlata, Suzanne Frances
• Rulfs, Jill
• Doyle, James Kevin
• Buckholt, Michael Allan

Year

• 2023

UN Sustainable Development Goals

• 3 - Good Health and Well-being

Date created

• 2023-04-26

Resource type

• Major Qualifying Project

Major

• Biotechnology
• Biochemistry

Source

• E-project-042623-234731

Rights statement

• In Copyright

Last modified

• 2023-06-18