Student Work
Targets of Filastatin, A Chemical Inhibitor of Adhesion and Morphogenesis by Pathogenic Fungi
公开Candida albicans is one of the most common fungal pathogens associated with opportunistic and nosocomial infections. Infection is often initiated through formation of a biofilm, which is also drug resistant. A recently discovered small molecule called filastatin shows some promise as an inhibitor of biofilm formation and adhesion to polystyrene. A high-throughput screening assay was performed using a deletion mutant library in order to determine the functional pathway of filastatin. Results indicate that our drug may play a role in disrupting the iron metabolism pathway, particularly through genes regulated through Hap43 and Rim101.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- 贡献者
- Publisher
- Identifier
- E-project-050114-100341
- Advisor
- Year
- 2014
- Date created
- 2014-05-01
- Resource type
- Major
- Rights statement
关系
- 属于 Collection:
项目
Permanent link to this page: https://digital.wpi.edu/show/3r074w247