Candida albicans is one of the most common fungal pathogens associated with opportunistic and nosocomial infections. Infection is often initiated through formation of a biofilm, which is also drug resistant. A recently discovered small molecule called filastatin shows some promise as an inhibitor of biofilm formation and adhesion to polystyrene. A high-throughput screening assay was performed using a deletion mutant library in order to determine the functional pathway of filastatin. Results indicate that our drug may play a role in disrupting the iron metabolism pathway, particularly through genes regulated through Hap43 and Rim101.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Boyd, Michael J.
• Cabral, Damien Joseph

Colaboradores

• Jain, Charu

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050114-100341

Advisor

• Rao, Reeta Prusty
• Dempski, Robert E.

Year

• 2014

Date created

• 2014-05-01

Resource type

• Major Qualifying Project

Major

• Interdisciplinary
• Biochemistry

Rights statement

• In Copyright