The LIG superfamily is characterized by its unique extracellular domain structure which contains a series of leucine-rich repeats (LRRs) followed by one or more Immunoglobulin (Ig) domains. Knowledge about biological pathways regulated by LIG family members is still at its infancy, though some members have been associated with novel biological functions such as inhibition of epidermal growth factor receptor (EGFR) in Drosophila and neuronal regeneration in humans. The goal of this project was: to design a high-throughput protein interaction assay to rapidly identify potential binding partners for LIG family members that may provide insight to their biological function.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Nguyen, Tran

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042512-223330

Advisor

• Gericke, Arne
• Duffy, Joseph B.

Year

• 2012

Date created

• 2012-04-25

Resource type

• Major Qualifying Project

Major

• Biochemistry
• Interdisciplinary
• Biology & Biotechnology

Rights statement

• In Copyright