Every year 1.8 million breast reconstruction surgeries are performed globally [1]. One of the most prominent methods used in these procedures is autologous fat grafting, where the patient's own fat tissue is taken from other parts of the body and reinjected into the breast. However, this procedure is only 30-70% effective as it often results in tissue loss and requires future revision surgeries [2]. To combat this problem, our team has designed a single-use device that decellularizes human adipose tissue in a closed environment, creating an ECM scaffold that can be immediately reinjected into the body during the fat grafting procedure. Specifically, the primary design includes a chamber with blades to mechanically lyse cells and a series of meshes to isolate the ECM from waste products. The goal of this device is to create a scaffold that can revascularize and be repopulated with cells when reinjected into the patient. This will reduce the need for revision surgeries and save surgeons a tremendous amount of time in the OR.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Philbrook, Emily
• Dodda, Neeraj
• Hankaoui, Sammy
• Noel, Sophia

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042522-112952
• 63376

Keyword

• Breast Reconstruction
• Fat Graft
• Extracellular Matrix
• Surgical device
• Scaffold
• Decellularization

Advisor

• Page, Raymond L.

Year

• 2022

Sponsor

• Dr. Giorgio Giatsidis

Date created

• 2022-04-25

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright

Last modified

• 2024-04-03