Today, an estimated 38,000 new HIV infections still occur in the United States (CDC, 2020). During the early signs of immune recognition by T cells, virus-derived peptides are presented by MHC molecules on the cellular surface. In HIV infection, immune responses and immune protection are not very well defined. In this project, we analyze HIV-specific patterns during antigen processing and presentation and develop computational tools to aid in the process of the analyses. From this area of study, further advancement in protein degradation analyses and in immunopeptidome definition may help in identifying targets for efficient immune clearance and a future vaccine design.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Le, Ann-Elizabeth V.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-051720-011635

Advisor

• Korkin, Dmitry

Year

• 2020

Sponsor

• Ragon Institute of MGH and Harvard
• MIT

Date created

• 2020-05-17

Resource type

• Major Qualifying Project

Major

• Bioinformatics & Computational Biology

Rights statement

• In Copyright