The Creation and Utilization of Bioinformatics Tools to Study Patterns of the Presented HIV Immunopeptidome Public
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Today, an estimated 38,000 new HIV infections still occur in the United States (CDC, 2020). During the early signs of immune recognition by T cells, virus-derived peptides are presented by MHC molecules on the cellular surface. In HIV infection, immune responses and immune protection are not very well defined. In this project, we analyze HIV-specific patterns during antigen processing and presentation and develop computational tools to aid in the process of the analyses. From this area of study, further advancement in protein degradation analyses and in immunopeptidome definition may help in identifying targets for efficient immune clearance and a future vaccine design.
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