Engineering of 3D scaffolds for tissue repair requires the ability to align cells to mimic cell orientations of native tissues. Our study focused on utilizing electrospinning technology to develop 3D nanofiber scaffolds whose alignment can be customized to mimic the microarchitecture of a tissue. Current electrospinning techniques have limited control of fiber orientation. We engineered a collection plate that can be adapted to produce 3D biomaterial scaffolds for use with commercially available electrospinning units. The custom fiber aligned scaffolds were seeded with green fluorescent protein (GFP) expressing cells to show viability for cell seeding and alignment along the fiber direction. The major device design characteristics and results are presented in this report.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Brinkmann, Derek Michael
• Davis, Grace Marion
• Dow, Timothy Curtis
• Sellman, Zachary Eugene

贡献者

• Wall, Lisa

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042816-103632

Advisor

• Ambady, Sakthikumar

Year

• 2016

Date created

• 2016-04-28

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright