Robust Assay to Study Associative Learning in C. elegansPublic
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Aging is a natural process that leads to a decline in physical and often mental abilities. It also leads to risk of degenerative diseases such as dementia. This project designed a system to allow for study of the effects of aging through use of associative learning in C. elegans. This system includes a microfluidic device that allows for study of adult C. elegans where previously devices only allowed for larval and smaller adult C. elegans. A light device was created to provide conditioned stimulus whose behavioral response could be mediated by pairing with attractive chemical stimuli to test associative learning. The designed system is capable of versatile experiments in which associative learning can be assessed and compared across ages, gender, and genetic mutants.
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