Primary cilia are sensory organelles that act as signaling hubs found on the surface of most cells in vertebrates. The goal of this project was to use C. elegans as a model to study the mechanisms by which cilia respond to physiological stress. C. elegans were subjected to heat and cold-stress assays, and their ciliated neurons were imaged to examine stress response. Primary cilia exhibited shortening in response to both heat and cold shock. Understanding the mechanisms by which cilia respond to stress may allow researchers to reverse adverse effects of environmental stress on ciliary signaling and associated disorders.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Quinn-Cyr, Katelyn

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050124-133421
• 122304

Keyword

• cilia
• C. elegans
• stress

Advisor

• Doyle, James Kevin
• Nechipurenko, Inna

Year

• 2024

Date created

• 2024-05-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Source

• E-project-050124-133421

Rights statement

• In Copyright

Last modified

• 2024-05-17