Feed-forward Control System for Fed-batch Development in Mammalian Bioreactors
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open in viewerIn this report, a more efficient technique to produce mAbs from Chinese Hamster Ovary cells in fed-batch systems is presented. A feed-forward control mechanism was created with BioXpert. The results are not conclusive due to lack of replicates to demonstrate reproducibility. If they are correct, it may be concluded that feed-forward control system was successfully implemented on the fed-batch bioreactors via BioXpert. Titer results from BioXpert experiments yielded higher results than manual feed-forward and similar to previous feedback experiments. For future work, it is recommended to repeat BioXpert feed-forward experiment with two or more replicates maintaining same cell line and using more frequent feeding schedule by keeping total daily feeding amount the same.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042408-160443
- Advisor
- Year
- 2008
- Sponsor
- Date created
- 2008-04-24
- Resource type
- Major
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