Student Work
DOG BREED DIFFERENCES IN CYTOCHROME P-450 ISOFORMS IN LIVER MICROSOMES
PublicGreyhounds have been found to have decreased rates of clearance of the anesthetic propofol, in addition to a longer recovery period, as compared with other breeds of dog. Clearance of propofol involves hydroxylation, which has been shown to be mediated by cytochrome P-450 (CYP), a microsomal mixed-function oxidase system. Greyhound, beagle, and mixed-breed microsomal liver samples were quantitatively analyzed by the Western Blot technique for a variety of CYP isoforms. The amount of this drug-metabolizing enzyme present in greyhounds at least partially explains the pharmacokinetic differences.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 05D423M
- Advisor
- Year
- 2005
- Date created
- 2005-01-01
- Resource type
- Major
- Rights statement
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