Stress Granules (SGs) are cytoplasmic bodies where mRNAs are stored during cellular stress to inhibit their translation. FMRP localizes to SGs and regulates mRNA translation; we hypothesized that SGs may differ in FXS and unaffected cells. Our results suggest altered stress responses may contribute to the pathophysiology of FXS. Additionally, literature shows that patients with intellectual and developmental disabilities (IDD) experience an increased rate of ED admissions. I hypothesized that IDD individuals would have different trends in their diagnoses due to the differing stress response. I studied a group of IDD individuals' ED visits compared to national averages and the infection and injury rates were found to be elevated.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Burke, Brianna Rose

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042419-103616

Advisor

• Faber, Brenton
• Farny, Natalie

Year

• 2019

Sponsor

• Canton-Potsdam Hospital (PW)

Date created

• 2019-04-24

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright